Conference On Retroviruses And Opportunistic Infections (CROI) 2015--Agenda/Schedule Of Events

Agenda/Schedule Of Events
Preliminary Agenda/Schedule of Events

Sunday, February 22, 2015
3:00 PM – 6:00 PM	Registration and Conference Materials Available for Pick-up
Monday, February 23, 2015
7:00 AM – 7:00 PM	Registration and Conference Materials Available for Pick-up
9:00 AM – 12:30 PM	Program Committee Workshop for New Investigators and Trainees Location: Room 6E Conveners: Scott M. Hammer and John W. Mellors (These preconference workshops are designed for Young Investigators but are open to all registered CROI attendees) A Path to an HIV Vaccine Galit Alter Animal Models of HIV Prevention and Cure Guido Silvestri HIV Prevention 2.0: What’s Next? Susan P. Buchbinder Pathogenesis of HIV Complications Peter W. Hunt HIV Cure Research John M. Coffin
1:00 PM – 2:00 PM	Martin Delaney Presentation: How to End the HIV Epidemic: Community Perspectives Location: Room 6E Panelists: Steven F. Wakefield, Connie L. Celum, MD, MPH, Damon L. Jacobs, LMFT, Matthew V. Sharp
2:30 PM – 4:30 PM	CONCURRENT WORKSHOPS Clinical Trial Design and Analysis Location: Room 6E  Conveners: Susan P. Buchbinder and Richard E. Chaisson Getting SMART About Innovative Designs for Studying Effectiveness: The Case of Adaptive Implementation Interventions Daniel Almirall The Clinical Pharmacology of Medication Adherence Terrence Blaschke Epidemiological and Biostatistical Issues in Studying Rare Events in HIV Stephen J. Gange Frontiers in Laboratory Science Location: Room 6D  Conveners: Galit Alter and Amalio Telenti Measuring Immunity 1 Cell at a Time Mario Roederer Studying Heterogeneity With Single Cell RNA Sequencing Simon Quenneville Integration-Site Analysis Frederic D. Bushman Discovery and Modeling of Genomic Regulatory Networks With Big Data Hamid Bolouri Hepatitis C Virus Location: Room 613  Conveners: Juergen K. Rockstroh and David L. Thomas Acute HCV: Is It Still Important to Diagnose and Treat? Arthur Y. Kim Chronic Genotype 1 Infection Debika Bhattacharya HCV Genotype 3: Our Next Challenge Arthur Y. Kim HCV Cirrhotics With Early Decompensation Marion G. Peters
5:00 PM – 7:00 PM	OPENING SESSIONS Bernard Fields Lecture: Hepatitis C: Light at the End of the Tunnel  Location: 4AB Auditorium Charles M. Rice, PhD N’Galy-Mann Lecture: Antiretroviral Therapy: Past, Present, and Future  Location: 4AB Auditorium David A. Cooper, MBBS, MD, DSc
7:00 PM – 9:30 PM	Welcome Reception All registered CROI attendees are invited to join us for a Welcome Reception immediately following the Opening Reception on Monday, February 23, 2015, from 7:00 PM to 9:30 PM. This will be a private event hosted at Nordstrom’s Flagship store in Downtown Seattle, at 500 Pine Street (Cross street 5th Avenue). This unique Welcome Reception will offer attendees the opportunity to experience a private shopping experience while enjoying passed hors d’oeuvres and beverages in a beautiful and unique setting.
Tuesday, February 24, 2015
7:00 AM – 7:00 PM	Registration and Conference Materials Available for Pick-up
8:30 AM – 9:00 AM	Plenary Session 1:  PrEP for HIV Prevention: What We Know and What We Still Need to Know for Implementation Location: 4AB Auditorium Raphael J. Landovitz, MD
9:00 AM – 9:30 AM	Plenary Session 2:  Specific HIV Integration Sites Linked to Clonal Expansion and Persistence of Cells Location: 4AB Auditorium  Stephen H. Hughes, PhD
9:30 AM – 10:00 AM	Break
10:00 AM – 12:15 PM	ORAL ABSTRACT SESSIONS Preventing HIV and HSV-2: What Will It Take? Location: Room 6AB  Moderators: Sharon L. Hillier and Jorge Sanches Pragmatic Open-Label Randomised Trial of Preexposure Prophylaxis: The PROUD Study Sheena McCormack et al. On Demand PrEP With Oral TDF-FTC in MSM: Results of the ANRS Ipergay Trial Jean-Michel Molina et al. Near Elimination of HIV Transmission in a Demonstration Project of PrEP and ART Jared Baeten et al. Scale-Up of Preexposure Prophylaxis in San Francisco to Impact HIV Incidence Robert M. Grant et al. FACTS 001 Phase III Trial of Pericoital Tenofovir 1% Gel for HIV Prevention in Women Helen Rees et al. Effect of Oral and Gel Tenofovir on Genital HSV Shedding in Immunocompetent Women Rachel A. Bender Ignacio et al. Injectable Hormonal Contraception Use and Women’s Risk for HSV-2 Acquisition Mary K. Grabowski et al. Effect of Financial Incentives on Linkage to Care and Viral Suppression: HPTN 065 Wafaa M. El-Sadr et al. Medical Male Circumcision of HIV-Infected Men Reduces Long-Term Penile HIV Shedding Jordyn L. Manucci et al. Prevention, Diagnosis, and Treatment of Pediatric HIV Infection Location: Room 613 Moderators: Carey Farquhar and Annette H. Sohn PROMISE: Efficacy and Safety of 2 Strategies to Prevent Perinatal HIV Transmission Mary Glenn Fowler1 et al. Most Breastfeeding Women With High Viral Load Are Still Undiagnosed in Sub-Saharan Africa David Maman et al. Delayed HIV Detection in Infants Exposed to ARV Prophylaxis During Breastfeeding Caroline C. King et al. Evaluation of the Alere q for Point-of-Care Early Infant HIV Diagnosis in South Africa Nei-Yuan Hsiao et al. Early ART and Sustained Virological Suppression Limits HIV Proviral DNA Reservoir: CHER Evidence Helen A. Payne et al. Long-Term Outcomes of HIV-Infected Children Initiating NVP vs LPV/r-Based Treatment Linda Barlow-Mosha et al. Structural Cardiovascular Changes Are Reversible in HIV-Infected Children in Zambia and Uganda Julia M. Kenny et al. ART With Weekends Off Is Noninferior to Continuous ART in Young People on EFV+2NRTI Karina M. Butler Cellular Dynamics, Sensing, and Viral Restriction Location: Room 615 Moderators: Jaisri Lingappa and Aine McKnight Envelope Trimer Numbers Required for Entry Steer HIV-1 Infectivity and Entry Kinetics Alexandra Trkola et al. HIV-1 Accessory Protein Function: Evaluating VPU-Dependent Host Factor Degradation Prashant Jain et al. HIV-1 Adaptation to Humans Involved Interactions of Vpr With the DNA Damage Response Oliver I. Fregoso et al. The HIV-1 Protease Can Interact With RNA to Dramatically Enhance Its Activity Marc Potempa et al. PQBP1 Is a Retrovirus-Specific Sensor Mediating cGAS/IRF3-Dependent Innate Responses Sunnie M. Yoh et al. Mucosal HIV-1 Transmission Specifically Selects for Type 1 Interferon-Resistant Viruses Shilpa Iyer et al. The Dynamics of HIV-1 RNA Near the Plasma Membrane During Virus Assembly Luca Sardo et al. Mechanisms of Dendritic Cell-Mediated Transfer of HIV-1 to CD4+ T Lymphocytes Mickael M. Menager et al.  New Discoveries in HIV Pathogenesis Location: Room 6D Moderators: Irini Sereti and Don Sodora Inflammation Persists Despite Early Initiation of ART in Acute HIV Infection Netanya S. Utay et al. HIV Burden and Biomarker Associations With Colonic HIV RNA During Acute HIV Infection Trevor A. Crowell et al. Identification and Characterization of Individual HIV-Infected CD4 T Cells Ex Vivo Joseph Casazza et al. Efficacy of HIV-1 Monoclonal Antibody Immunotherapy in Acute SHIV-Infected Macaques Diane L. Bolton et al. HIV-1 Infections With Multiple Founders Are Associated With Higher Viral Loads Morgane Rolland et al. Post-Treatment Controllers Have Particular NK Cells With High Anti-HIV Capacity: VISCONTI Study Daniel Scott-Algara et al. Antiretroviral Therapy Preserves Polyfunctional HIV-1–Specific CD8 T Cells With Stem-Cell–Like Properties Selena Vigano et al. In Vitro Replication and Interferon-Alpha Resistance of Transmitted HIV-1 Variants Zachary Ende et al. HVTN505 Breakthrough Sequences Showed HIV Vaccine-Associated Differences in Env-gp120 Morgane Rolland et al.
12:15 PM – 1:15 PM	Lunch on Own
1:30 PM – 2:30 PM	THEMED DISCUSSIONS Next Generation of Next-Generation Sequencing Location: Room 615 Discussion Leader: Davey M. Smith PCR-Free Full Genome Characterization of Diverse HIV-1 Strains by Nextgen Sequencing Viswanath Ragupathy et al. Pan-HIV Next-Gen Sequencing Strategy for Viral Surveillance Michael G. Berg et al. Near Full Length HIV-1 Sequencing to Understand HIV Phylodynamics in Africa in Real Time Tulio de Oliveira et al. Present Applications of a High-Throughput, Single Measure HIV Genomic Incidence Assay Ha Youn Lee et al. A Comprehensive Analysis of Primer IDs to Study Heterogenous HIV-1 Populations David Seifert et al. Analysis of Resistance Haplotypes Using Primer IDs and Next Gen Sequencing of HIV RNA Valerie F. Boltz et al.  HIV/CMV Interactions in Transmission and Pathogenesis Location: Room 613 Discussion Leader: Victor Appay Effect of CMV and HIV Replication on T-Cell Exhaustion and Senescence During ART Jennifer M. Dan et al. HIV Myeloid Derived Suppressor Cells Control Cytomegalovirus Inflammation by IL-27 Ankita Garg et al. Persistent Elevation of Inflammation Markers in HIV+ Persons With CMV Disease Melissa Schechter et al. sCD163 Increase in HIV/CMV-Coinfected Subjects Included in ICONA Cohort Serena Vita et al. Genital CMV Shedding Predicts Syphilis Acquisition in HIV-Infected MSM on ART Sara Gianella Weibel et al. Leaky Latency Location: Room 6D Discussion Leader: Monique Nijhuis Defective HIV-1 Proviruses Can Be Transcribed Upon Activation Ya-Chi Ho et al. Influenza Vaccination Increases HIV-1 Transcription During Antiretroviral Therapy Christina C. Yek et al. Measurements of Viral Transcription in Elite Suppressor CD4+ T Cells Christopher W. Pohlmeyer et al. Minor Contribution of Host-HIV Readthrough Transcripts to the Level of HIV-1 gag RNA Alexander Pasternak et al. Characterizing the Active HIV Reservoir on ART: Cell-Associated HIV RNA and Viremia Feiyu Hong et al. Nascent LTR-Driven Transcription Can Lead to Translation of HIV Proteins in Resting CD4+ T Cells Laura DeMaster et al. Fat Without Borders: Metabolic Complications in Resource-Limited Settings Location: Room 6AB Discussion Leader: Miriam Rabkin Obesity and Inflammation in Resource-Diverse Settings of ART Initiation Kristine M. Erlandson et al. Body Composition Outcomes at 96 Weeks in the SECOND-LINE RCT DXA Substudy Mark A. Boyd et al. Bone Quality by Quantitative Ultrasound at the Radius Does Not Differ in ART-Naïve HIV+ and HIV- Rwandan Women Eugene Mutimura et al. Predictors and Outcomes of Incident High Cholesterol in Adults on ART in South Africa Matt P. Fox et al. Metabolic Changes and Second-Line ART in Africa (2LADY/ANRS 12169 Trial) Amandine Cournil et al.  Hormonal Contraceptives: Enduring Controversy Location: Room 6C Discussion Leader: Betsy Herold Estrogen Replacement in Healthy Postmenopausal Women Reduces %CCR5+ CD4+ T Cells Amie Meditz et al. CCR5 Expression in HIV-Uninfected Women Receiving Hormonal Contraception Athe Tsibris et al. Progesterone Increases Are Associated With HIV Susceptibility Factors in Women Richard E. Haaland et al. Changes in Vaginal Microbiota and Cytokines in HIV-1-Seronegative Women Initiating DMPA Alison C. Roxby et al. Circumcision: Evolving Knowledge and Practice Location: Room 6E Discussion Leader: Emmanuel Njeuhmeli Mobile VMMC Teams in Tanzania See Older Clients and Have Higher Followup Rates Augustino M. Hellar et al. High Acceptability of PrePex™ Device in Routine Programmatic Settings in Rwanda Eugene Rugwizangoga et al. Potential Protection From HIV Transmission by Penile Cuttings in Papua New Guinea Ivy H. Shih et al. HSV-2 Shedding From Male Circumcision Wounds Among HIV-Infected Men Mary K. Grabowski et al. Self-Selection of Circumcision Acceptors, Risk Compensation and Effectiveness of Circumcision Among Service Recipients, Rakai, Uganda Joseph Kagaayi et al.
2:30 PM – 4:30 PM	Poster Abstract Sessions by Category All poster sessions will be held in the Poster Hall. A. Virology B. Molecular Epidemiology and HIV/SIV Evolution C. Pathogenesis—Human and Animal Studies E. Host Immune Responses to Infection, Vaccines, and Immunotherapy F. HIV Persistence, Reservoirs, Latency, Eradication, including Gene Therapy G. Neuropathogenesis H. Clinical Pharmacology J. Antiretroviral Therapy: Randomized Clinical Trials K. Antiretroviral Therapy: Observational Studies M. HIV Diagnostics N. Hepatitis Viruses O. HIV–Related and Non–HIV-Related Malignancies P. Cardiovascular Complications of HIV Infection and Antiretroviral Therapy Q. Other Complications of HIV Infection and Antiretroviral Therapy R. Tuberculosis and Other Opportunistic Infections S. HIV in Women and Women’s Health T. Maternal/Fetal HIV U. Pediatrics and Adolescents V. Prevention and Intervention Studies W. Epidemiology X. Health Care Delivery and Health Systems Z. Population and Economic Modeling
4:00 PM – 6:00 PM	CONCURRENT SYMPOSIA Harnessing Antibodies for Prevention and Therapeutics Location: Room 6C Conveners: Leonidas Stamatatos and Susan Zolla-Pazner Potentiating Protective Antibody Activity: A System Serology Approach Margaret E. Ackerman Impact of Repetitive Protein Boosting on RV305 HIV-1 Vaccine-Induced Antibodies Georgia D. Tomaras Immunoprophylaxis by Gene Transfer: Shortcut to an HIV Vaccine Phil Johnson Broadly Neutralizing Antibodies for HIV-1 Eradication Strategies Dan H. Barouch Current Issues in HIV-Related Malignancies Location: Room 6D Conveners: Margaret Z. Borok and Robert Yarchoan HIV-Associated Malignancies: The Worldwide Epidemic James J. Goedert Viral Oncogenesis: Evolving Concepts Shannon C. Kenney AIDS Lymphoma: Advances and Existing Challenges Ariela Noy HIV Malignancies in Low and Middle Income Countries: A Double Burden of Disease Jackson Orem Current Imperatives in HIV Prevention and Treatment Location: Room 6AB Conveners: Wafaa M. El-Sadr and Lucy Nganga How Has HIV Prevention Affected the Spread of Other Sexually Transmitted Infections? Marie Laga HIV Risks and Vulnerabilities Among Gay Men and Other Men Who Have Sex With Men Across Sub- Saharan Africa Stefan Baral An Expanded Behavioral Paradigm for Treatment and Prevention of HIV-1 Thomas J. Coates Social Protection, Financial Incentives, and Prevention of HIV David Wilson ORAL ABSTRACT SESSION NeuroAIDS Pathogenesis and Antiretroviral Therapy Location: Room 613 Moderators: Lucette A. Cysique and Alan Winston Randomized Clinical Trial of Antiretroviral Therapy for Prevention of HAND Scott Letendre et al. Neurocognitive Function in Africans Failing First-Line ART and Responses to Second Line Andrew D. Kambugu et al. Compartmentalized HIV Rebound in the CNS After ART Interruption Sara Gianella Weibel et al. Impaired Blood-Brain Barrier Integrity Is Associated With Neuronal Injury in HIV Birgitta Anesten et al. Cortical and Subcortical Brain Volumes in Primary HIV Infection Patrick W. Wright et al. IRF4 Transcription Factor Associated With Integrated HIV DNA in Brain Macrophages Benjamin B. Gelman et al. Longitudinal Assessment of Blood Brain Barrier Disruption in Primary HIV Infection Elham Rahimy et al. Declining Prevalence of HIV-Associated Neurocognitive Disorders in More Recent Years Carmela Pinnetti et al.
6:30 PM – 7:30 PM	SPECIAL SESSION  Ebola Virus Disease: Responding to the Challenge Location: Room 6E Moderators: Kevin M. DeCock and Wafaa M. El-Sadr (Light snacks and beverages will be provided) The Médecins Sans Frontières Experience With The Current Ebola Outbreaks Gilles Van Cutsem MD, DTMH, MPH  Ebola Vaccines, Passive Immunotherapy, and Antiviral Treatment H. Clifford Lane, MD
Wednesday, February 25, 2015
8:00 AM – 6:00 PM	Registration and Conference Materials Available for Pick-up
8:30 AM – 9:00 AM	Plenary Session 1: Preventing Pediatric HIV and Managing HIV-Infected Children: Where Are We Now and Where Are We Going? Location: 4AB Auditorium  Diana Gibb, MSc, MD
9:00 AM – 9:30 AM	Plenary Session 2: Directing Chronic Virus Infection Through Viral Regulation of Innate Immune Defenses Location: 4AB Auditorium Michael Gale Jr, PhD
9:30 AM – 10:00 AM	Break
10:00 AM – 10:30 AM	SPECIAL PRESENTATION  Controlling the Epidemic and Delivering on the Promise of an AIDS-Free Generation Ambassador Deborah L. Birx, MD Location: Room 6E
10:00 AM – 12:15 PM	ORAL ABSTRACT SESSIONS Intracellular and Clinical Pharmacology, Drug Interactions, and Adherence Location: Room 615 Moderators: Reina Bendayan and Marta Boffito Scientific Overview: The Clinical Pharmacology of HIV Prevention Marta Boffito Intracellular Pharmacokinetics of Sofosbuvir In Vivo Joseph Rower et al. Drug-Drug Interactions Between Anti-HCV Regimen Ledipasvir/Sofosbuvir and Antiretrovirals Polina German et al. Emtricitabine-Triphosphate in Dried Blood Spots (DBS) as a Marker of Recent Dosing Jose R. Castillo-Mancilla et al. Impact of EFV PK/PG on Neuropsychological Performance in Older HIV+ Patients Uriel S. Sandkovsky et al. Levonorgestrel Implant + EFV-Based ART: Unintended Pregnancies and Associated PK Data Kimberly K. Scarsi et al. A Phase IV PrEP Study Reveals Limited Ex Vivo Potency of Oral Maraviroc Against HIV-1 Julie Fox et al. KS and Cervical/Anal Dysplasia: Tale of 2 Tumors and TB and Other OIs Location: Room 613 Moderators: Corey Casper and Timothy Sterling Pomalidomide for Kaposi Sarcoma in People With and Without HIV: A Phase I/II Study Mark N. Polizzotto et al. Prognostic Model for Patients With Kaposi Sarcoma Treated With ART Alone in Africa Jeffrey Martin et al. One-Year Follow-up of HIV+ Women Screened With VIA, Cytology and HPV in South Africa Cynthia Firnhaber et al. High Rate of HSIL on HRA in HIV+ Women Not Meeting Criteria for Anal Cancer Screening Fanny Ita-Nagy et al. Xpert MTB/RIF Ultra: A New Near-Patient TB Test With Sensitivity Equal to Culture David Alland et al. Majority of XDR TB Cases Are Due to Transmission in a High-HIV-Prevalence Setting N. Sarita Shah et al. Linkage to HIV/TB Care in South Africa: A Randomized Trial of Health Navigators Ingrid V. Bassett et al. Is It Safe to Stop Cotrimoxazole in Adults on ART: COSTOP, a Noninferiority RCT Jonathan B. Levin et al. High-Dose Rifampin, SQ109 and Moxifloxacin for Treating TB: The PanACEA MAMS-TB Trial Martin J. Boeree et al.  Factors Affecting HIV Care and Outcome: Global Perspective Location: Room 6E Moderators: Ruanne V. Barnabas and Elizabeth Bukusi Special Presentation: PEPFAR 3.0: Controlling the Epidemic and Delivering on the Promise of an AIDS Free Generation Ambassador Deborah L. Birx Joint Estimation of HIV Progression and Survival: A Pooled Analysis of 25 Countries Tara D. Mangal Impact of Emergency Department HIV Testing and Linkage to Care: 25 Years’ Experience Gabor Kelen et al. Linkage to Care and Viral Suppression Among New HIV Diagnoses, New York City, 2006-13 Lucia V. Torlan et al. Care and Viral Suppression Among Women, 18 US Jurisdictions Ndidi Ike et al. Time Above 1500 Copies/ml: A Viral-Load Measure for Assessing Transmission Risk of HIV-Positive Patients in Care Lytt I. Gardner et al. Incidence and Risk Factors for Sexual Assault Among MSM and Young Women in Coastal Kenya Adrian D. Smith et al. Impact of the Ebola Epidemic on HIV Care in Macenta, Forest Guinea, 2014 David Leuenberger et al. New Insights into HIV Persistence, Latency Reversal, and Viremia Rebound Location: Room 6D Moderators: Françoise Barré-Sinoussi and Celsa A. Spina Durable Control of Viral Rebound in Humanized Mice by ABX464 Targeting Rev Functions Jamal Tazi et al. Residual Viremia Caused by Clonally Expanded Tumor-Infiltrating CD4+ Cells Francesco R. Simonetti et al. Analysis of HIV RNA in Single Cells Reveals Clonal Expansions and Defective Genomes Mary F. Kearney et al. Low-Level HIV Viremias Originate in Part From Infected Proliferating Cells Marta E. Bull et al. Treatment With a TLR7 Agonist Induces Transient Viremia in SIV-Infected ART-Suppressed Monkeys James B. Whitney et al. Panobinostat Broadly Activates Latent HIV-1 Proviruses in Patients Sarah E. Palmer et al. The Size of the Active HIV Reservoir Predicts Timing of Viral Rebound Jonathan Li et al. Biomarkers to Predict Viral Rebound at Antiretroviral Therapy Interruption in SPARTAC John Frater et al. HIV-1 Diversity and Tropism of Rebound Virus After Treatment Discontinuation Maria M. Bednar et al.
12:15 PM – 1:15 PM	Lunch on Own
1:30 PM – 2:30 PM	THEMED DISCUSSIONS Interferon: Triggers and Effectors Location: Room 615 Discussion Leader: Martin R. Jakobsen HIV-1 Exploits CD169 to Evade IFNα-Induced Antiviral State in Myeloid Cells Hisashi Akiyama et al. HIV and SIV Inhibition by RNA-Associated Early Stage Antiviral Factor (REAF) Aine McKnight Regulation of the Innate Immune Sensing of HIV by the Viral Capsid and the Cytosolic DNA Sensor cGAS Nicolas Manel Mapping Vpx and Vpr Specificity in Antagonism of SAMHD1 Chelsea Spragg et al. A Surprising New Function of SAMHD1 as a Pro-Pathogenic Factor in HIV Infection Gilad Doitsh et al. Characterization of the Activity of an Innate Immunity Protein, the Apolipoprotein L6 Nitisha Pyndiah et al. New Technologies in Assessing Drug Interactions and Systemic and Intracellular Phrmacology Location: Room 613 Discussion Leader: Tim R. Cressey Pharmacokinetic Interactions Between Antidiabetics and Efavirenz Using PBPK Modeling Catia Marzolini et al. In Silico Simulation of Interaction Between Rifampicin and Boosted Darunavir Marco Siccardi et al. Pharmacogenetics of Pregnancy-Induced Changes in Efavirenz Pharmacokinetics Adeniyi Olagunju et al. Antiretroviral Drug Transporters and Metabolic Enzymes in Human Testicular Tissue Billy Huang et al. Imaging the Spatial Distribution of Efavirenz in Intact HIV Tissue Reservoirs Elias P. Rosen et al. Cancers in Young and Old and Lung Cancer in HIV Location: Room 6D Discussion Leader: Eric A. Engels Cancer in HIV-Infected Children: Record Linkage Study in South Africa Matthias Egger et al. High Cancer Risk Among the HIV-Infected Elderly in the United States Elizabeth L. Yanik et al. Smoking Outweighs HIV-Related Risk Factors for Non–AIDS-Defining Cancers Keri N. Althoff et al. High Frequency of Early Lung Cancer Diagnosis With Chest CT in HIV-Infected Smokers Alain Makinson et al. CD4 Measures as Predictors of Lung Cancer Risk and Prognosis in HIV Infection Keith Sigel et al.  Cryptococcal Meningitis: Host Response, Treatment, and Outcomes Location: Room 6E Discussion Leader: Judith A. Aberg Local and Systemic Humoral Responses to Cryptococcal Meningitis in Patients With AIDS Erin E. Finn et al. Antiretroviral Therapy Alters the CSF Immune Response in Cryptococcal Meningitis James E. Scriven et al. Detrimental Outcomes of Unmasking Cryptococcal Meningitis With Recent ART Initiation Joshua Rhein et al. Impact of ART on Mortality in Cryptococcal Meningitis Patients: High-Income Settings Suzanne M. Ingle et al. Adjunctive Sertraline for the Treatment of HIVAssociated Cryptococcal Meningitis Joshua Rhein et al. Serosorting and Seroadaptive Behavior: What's Your Position? Location: Room 6AB Discussion Leader: Andrew E. Grulich Trends in Sexual Behaviors Among Men Who Have Sex With Men in the United States, the Role of Antiretroviral Therapy and Seroadaptive Strategies Gabriela Paz-Bailey et al. Changes in Condomless Sex and Serosorting Among MSM After HIV Diagnosis Christine M. Khosropour et al. Serosorting and Sexual Risk Behavior Influenced by Perceived HIV Serostatus Among MSM Kathleen A. Brady et al. Use of the Seroadaptive Strategies of Sexual Positioning and Serosorting by MSM in Nigeria Cristina M. Rodriguez-Hart et al. Economic Implications of ART Location: Room 6C Discussion Leader: John Blandford The Lifetime Medical Cost Savings From Preventing HIV in the United States Bruce R. Schackman et al. Survival Benefits Attributable to the Brazilian National ART Policy Paula M. Luz et al. The Cost-Effectiveness of Early ART Initiation in South Africa: A Quasi-Experiment Jacob Bor et al. Community-Based Strategies to Strengthen the Continuum of HIV Care Are Cost-Effective Jennifer A. Smith et al. Global Fund Cost Projections for Implementing WHO 2013 Guidelines Obinna Onyekwena et al.
2:30 PM – 4:30 PM	Poster Abstract Sessions by Category All poster sessions will be held in the Poster Hall. A. Virology B. Molecular Epidemiology and HIV/SIV Evolution C. Pathogenesis—Human and Animal Studies E. Host Immune Responses to Infection, Vaccines, and Immunotherapy F. HIV Persistence, Reservoirs, Latency, Eradication, including Gene Therapy G. Neuropathogenesis I. Antiretroviral Therapy: Preclinical Studies K. Antiretroviral Therapy: Observational Studies M. HIV Diagnostics N. Hepatitis Viruses O. HIV-Related and Non–HIV-Related Malignancies P. Cardiovascular Complications of HIV Infection and Antiretroviral Therapy Q. Other Complications of HIV Infection and Antiretroviral Therapy U. Pediatrics and Adolescents V. Prevention and Intervention Studies W. Epidemiology X. Health Care Delivery and Health Systems Y. Implementation Science Z. Population and Economic Modeling
4:00 PM – 6:00 PM	CONCURRENT SYMPOSIA Making Sense of Sensing: Innate Immunity and HIV Infection Location: Room 613 Conveners: Nathaniel Landau and Jairam R. Lingappa Role of Tetherin in the Evolution and Spread of HIV-1 Daniel Sauter Viral Accessory Proteins and Escape from Innate Immune Sensing Nadine Laguette Innate Sensing and Signaling to HIV-1 in Dendritic Cells Teunis Geijtenbeek How HIV-1 Evades DNA Sensors Vineet KewalRamani Advancing HIV Prevention: Lessons From Biology, Medicine, and Public Health Law Location: Room 6D Conveners: Meg C. Doherty and Jeanne M. Marrazzo The Biology of HIV Transmission: What We Think We Know and How We Know It Julie Overbaugh HIV Phylogenetics: Lessons for HIV Prevention Christophe Fraser Optimizing ART: Treatment as Prevention in the US: Will It Be Enough? Richard A. Elion Criminalizing HIV: Recent Experience in the United States and Africa to Update Laws and Policies to Promote the Public Health Jeffrey Crowley Tuberculosis: Magic Bullets and Moving Targets Location: Room 6E Conveners: Alison Grant and Ilesh V. Jani Advances in Mycobacterial Diagnostics Mark P. Nicol New Medications, Innovative Approaches: Accelerate the TB Regimen Development Pipeline Michael Hoelscher Tuberculosis in Pregnancy Amita Gupta Tuberculosis in Children Anneke C. Hesseling ORAL ABSTRACT SESSION New Antiretroviral Agents, Strategies, and HIV Drug Resistance Location: Room 6C Moderators: Constance Delaugerre and Richard Harrigan Tenofovir Alafenamide (TAF) in a Single-Tablet Regimen in Initial HIV-1 Therapy David Wohl et al. Antiviral Activity/Safety of a Second-Generation HIV-1 Maturation Inhibitor Max Lataillade et al. Early ART and IPT in HIV-Infected African Adults With High CD4 Count (Temprano Trial) Christine Danel et al. Antiretroviral Drug Screening Provides Key Insights Into HIV Drug Resistance Iris Chen et al. Untimed Drug Levels and Resistance in Patients Experiencing Low-Level HIV Viremia Alejandro Gonzalez-Serna et al. Pretreatment HIV Drug Resistance Increases Regimen Switch in Sub-Saharan Africa Tamara Sonia Boender et al. Impact of NRTI Cross-Resistance on Second-Line PI + NRTI Therapy Outcomes in Africa Nicholas Paton et al. Fitness Effects of Drug-Resistant Strains Across the United States HIV-1 Transmission Network Joel O. Wertheim et al. Dolutegravir Resistance Requires Multiple Primary Mutations in HIV-1 Integrase Wel Huang et al.
Thursday, February 26, 2015
8:00 AM – 12:00 PM	Registration and Conference Materials Available for Pick-up
8:30 AM – 9:00 AM	Plenary Session 1: Cardiovascular Disease in HIV Patients: An Emerging Paradigm and Call to Action Location: 4AB Auditorium  Steven K. Grinspoon, MD
9:00 AM – 9:30 AM	Plenary Session 2: The Price of Selling Sex: HIV Among Female Sex Workers—The Context and the Public Health Response Location: 4AB Auditorium  Frances Cowan, MD
9:30 AM – 10:00 AM	Break
10:00 AM – 12:15 PM	ORAL ABSTRACT SESSIONS Cardiovascular, Bone, and Kidney Health Location: Room 6C Moderators: Jennifer F. Hoy and Edgar T. Overton Statin Therapy Reduces Coronary Noncalcified Plaque Volume in HIV Patients: A Randomized Controlled Trial Janet Lo et al. Rosuvastatin Arrests Progression of Carotid Intima-Media Thickness in Treated HIV Grace A. McComsey et al. Calcified Plaque Burden Is Associated With Serum Gut Microbiota-Generated TMA in HIV Suman Srinivasa et al. Varenicline vs Placebo for Smoking Cessation: ANRS 144 Inter-ACTIV Randomized Trial Patrick Mercie et al. Body Composition Changes After Initiation of Raltegravir or Protease Inhibitors Grace A. McComsey et al. Fracture Prediction With Modified FRAX in Older HIV+ and HIV- Men Michael T. Yin et al. Exposure to Antiretrovirals (ARVs) and Development of Chronic Kidney Disease (CKD) Amanda Mocroft et al. Renal and Bone Safety of Tenofovir Alafenamide vs Tenofovir Disoproxil Fumarate Paul E. Sax et al. Special Presentation: Update on National Heart, Lung, and Blood Institute High-Impact AIDS Research Monica Shah Curing HCV: Mission Accomplished Location: Room 6AB Moderator: TBA The Burden of Liver Disease Among Persons With Hepatitis C in the United States Monina Klevens et al. High Efficacy of Daclatasvir/Asunaprevir/PR in HIV/HCV1-4 Null Responders (ANRS HC30) Lionel Piroth et al. High SVR Regardless of Time to Suppression With ABT-450/r/Ombitasvir & Dasabuvir+RBV David Wyles et al. The Paradox of Highly Effective Sofosbuvir Combo Therapy Despite Slow Viral Decline Jérémie Guedj et al. Real-World Pharmaceutical Costs in the Simeprevir/Sofosbuvir Era: $164,485 per SVR4 Kian Bichoupan et al. Impact of Deferring HCV Treatment on Liver-Related Events in HIV+ Patients Cindy Zahnd et al. Daclatasvir in Combination With Sofosbuvir for HIV/HCV Coinfection: ALLY-2 Study David Wyles et al. Ledipasvir/Sofosbuvir for 12 Weeks in Patients Coinfected With HCV and HIV-1 Susanna Naggie et al.  Reaching Populations: Demonstrating Impact Location: Room 6D Moderators: Sarah Fidler and Jessica E. Justman Population Viral Load in Three High HIV Prevalence Settings in Sub-Saharan Africa David Maman et al. Disparities in Engagement Within HIV Care in South Africa Simbarashe Takuva et al. Decentralizing Access to Antiretroviral Therapy Services for Adults in Swaziland Andrew F. Auld et al. Who Are the 10-Year AIDS Survivors on Antiretroviral Therapy in Haiti? Samuel Pierre et al. Nationwide Evaluation of Antiretroviral Therapy Coverage on Prevention in Rwanda: A Multisectional Time-Trend Analysis Edward Mills Impact of Male Circumcision Scale-Up on Community-Level HIV Incidence in Rakai, Uganda Xiangrong Kong et al. Effects of Antiretroviral Treatment on Health Care Utilization in Rural South Africa Jan A. Hontelez et al. The Impact of PEPFAR Abstinence and Faithfulness Funding Upon HIV Risk Behaviors in Sub-Saharan Africa Nathan C. Lo et al. The Impact of Antiretroviral Therapy on Adult Life Expectancy in Sub-Saharan Africa Georges Reniers et al. Immune Mechanisms: The Road to Protection Location: Room 613 Moderators: Katherine J. Bar and Bruce Walker Passively Acquired ADCC Activity in HIV-Infected Infants Correlates With Survival Caitlin Milligan et al. AAV-Expressed eCD4-Ig Protects Rhesus Macaques From Multiple SHIV-AD8 Challenges Michael Farzan HIV Neutralizing Antibodies Induced by Native-Like Envelope Trimers Rogier Sanders Efficacy Loss of BnAbs During HIV-1 Cell-Cell Spread Is Strain- and Epitope-Dependent Lucia Reh et al. Peripheral T Follicular Helper Cells With Universal Helper Activity in HIV Infection Hendrik Streeck et al. Redirected Killing of HIV-Infected T Cells by Germinal Center CD8 T Cells Constantinos Petrovas et al. IL-21 Reduces Inflammation and Virus Persistence in ART-Treated SIV-Infected Macaques Luca Micci et al. Discovery of CD8+ T Cell Epitopes Encoded by the HIV 5’ Leader Sequence Edward Kreider et al. Neutralizing Antibodies Differ Between HIV-1–Infected RV144 Vaccinees and Placebos Shelly J. Krebs et al.
12:15 PM – 1:15 PM	Lunch on Own
1:30 PM – 2:30 PM	THEMED DISCUSSIONS Identifying Recent Infections: Issues of False Recency Location: Room 615 Discussion Leader: Michael Busch A Generalized Entropy Measure of Viral Diversity for Identifying Recent HIV-1 Infections Julia W. Wu et al. Viral Load is Critical in Limiting False-Recent Results From HIV Incidence Assays Alex Welte et al. False Recent Rates for Two Recent Infection Testing Algorithms, South Nyanza, Kenya Clement Zeh et al. The Effect of HIV-1 Subtype A, C and D on Cross-Sectional Incidence Assay Performance Oliver B. Laeyendecker et al. Next Generation HCV Therapeutics: From Clinical Trials to the Clinic Location: Room 6AB Discussion Leader: Debika Bhattacharya German Cohort on Sofosbuvir-Based Therapy for HIV/HCV and HCV Infection (GECOSO) Stefan Mauss et al. Successful HCV Treatment With Direct Acting Antivirals in HIV/HCV Patients Claudia Hawkins et al. Effectiveness of Sofosbuvir/Simeprevir for HIV/HCV Patients in Clinical Practice Jay R. Kostman et al. Simeprevir and Sofosbuvir Regimens for Hepatitis C: Decompensation and Serious AEs Ponni V. Perumalswami et al. Majority of HIV/HCV Patients Need to Switch ART to Accommodate Simeprevir Ramakrishna Prasad et al. Sofosubuvir, Simeprevir, +/- Ribavirin in HCV Protease Inhibitor-Experienced Patients Kristen M. Marks et al.  Cardiovascular Risk Prediction: Can We Do Better? Location: Room 6E  Discussion Leader: Nina Friis-Moller Cumulative HIV Care Measures Highly Associated With Acute Myocardial Infarction Jorge L. Salinas et al. Cardiovascular Disease Risk Prediction in the HIV Outpatient Study (HOPS) Angela M. Thompson-Paul et al. Incidence and Risk of Myocardial Infarction (MI) by Type in the NA-ACCORD Daniel R. Drozd et al. HIV-Infected Veterans and the New ACC/AHA Cholesterol Guidelines: Got Statins? Meredith E. Clement et al. Evaluation of the ACC/AHA CVD Risk Prediction Algorithm Among HIV-Infected Patients Virginia A. Triant et al.  Keys to the Kingdom: Viral Suppression in Pregnant and Postpartum Women Location: Room 6D Discussion Leader: Laurent Mandelbrot Specific Effects of ZDV, 3TC and LPV/r on HIV-1 RNA Viral Load During Pregnancy Patumrat Sripan et al. Viral Suppression After Antiretroviral Therapy Initiation in Pregnancy in South Africa Landon Myer et al. Maternal Viral Load in the Context of PMTCT B+ Within the Kabeho Study in Kigali Emily A. Bobrow et al. ART Response Among Pregnant and Postpartum Women With Acute Versus Chronic HIV-1 Alison L. Drake et al. PEP: Remember Me? Location: Room 6C Discussion Leader: Kenneth H. Mayer Tenofovir/Emtricitabine Plus LPV/r vs MVC or Raltegravir for PEP: 2 Randomized Trials Lorna Leal et al. Rilpivirine-Emtricitabine-Tenofovir for HIV Nonoccupational Postexposure Prophylaxis Rosalind Foster et al. Significant Intolerability of Efavirenz in HIV Occupational Postexposure Prophylaxis Surasak Wiboonchutikul et al. Management of Acute HIV After Initiation of Postexposure Prophylaxis: Challenges and Lessons Learnt Goli Haidari et al.
2:30 PM – 4:30 PM	Poster Abstract Sessions by Category All poster sessions will be held in the Poster Hall. A. Virology B. Molecular Epidemiology and HIV/SIV Evolution C. Pathogenesis—Human and Animal Studies E. Host Immune Responses to Infection, Vaccines, and Immunotherapy F. HIV Persistence, Reservoirs, Latency, Eradication, including Gene Therapy G. Neuropathogenesis H. Clinical Pharmacology L. HIV Drug Resistance N. Hepatitis Viruses O. HIV-Related and Non–HIV-Related Malignancies Q. Other Complications of HIV Infection and Antiretroviral Therapy R. Tuberculosis and Other Opportunistic Infections S. HIV in Women and Women’s Health T. Maternal/Fetal HIV U. Pediatrics and Adolescents V. Prevention and Intervention Studies W. Epidemiology X. Health Care Delivery and Health Systems Y. Implementation Science Z. Population and Economic Modeling
4:00 PM – 6:00 PM	CONCURRENT SYMPOSIA From Pathways to Paradigms: Applications of Systems Biology to HIV/Host Interactions Location: Room 613 Conveners: Steven Bosinger and Raphael Gottardo Using Systems Approaches to Study Pathogenesis: Bridging Networks and Mechanisms Nevan Krogan Molecular Basis of T Cell Exhaustion E. John Wherry A Systems Biology Approach to Identify Targets and Mechanisms of HIV Latency and HIV Eradication Rafick P. Sekaly Translating Anti-HIV-1 Immune Mechanisms Into Clinical Interventions Sallie R. Permar Scale-Up of Interventions Location: Room 6D Conveners: Linda-Gail Bekker and Kevin M. De Cock From Equipoise to Efficacy to Millions Reached With Voluntary Medical Male Circumcision for HIV Prevention Jason B. Reed Scale-Up of HIV Interventions for People Who Inject Drugs: Quality and Coverage Anna Deryabina HIV Testing and Counseling: Emerging Issues, New Directions Rachel C. Baggaley Ten Years of Strengthening Laboratory Services and Systems: Then, Now, and the Future John Nkengasong HCV: New Frontiers and Controversies Location: Room 6E Conveners: Chloe M. Orkin and David Wyles Pathogenesis of Acute HCV Infection Ashwin Balagopal HCV Treatment as Prevention: Challenges and Opportunities Gregory Dore HCV Therapeutics: It’s the Virus, Stupid Mark Sulkowski HCV Therapeutics: Big Sticks With Big Stickers Marion G. Peters